zoom A court in Singapore has fined a bunker supplier after it pleaded guilty to providing bunker services at the Port of Singapore without a proper licence, the Maritime and Port Authority of Singapore (MPA) reports.JL Petroleum Pte Ltd pleaded guilty in court on August 18 to supplying bunkers without a valid licence issued by MPA.MPA had brought charges against JL Petroleum for supplying bunkers on 14 occasions between June 2 and June 25, 2013. In addition, JL Petroleum had also used the Bunker Delivery Notes belonging to Excel Petroleum Enterprise Pte Ltd for the deliveries, MPA says.MPA had cancelled Excel Petroleum Enterprise’s bunker supplier licence on January 15, 2014 for the company’s involvement in this case, as its actions had breached the terms and conditions of the licence.All bunker suppliers operating in the Port of Singapore must be licensed by MPA, and all licensees must adhere strictly to the terms and conditions of the licence.
Quebec’s public security minister is urging people in regions at risk of flooding not to take any chances and to follow the advice of civil security officials.Genevieve Guilbault spoke today as two days of heavy rain were forecast for the province, aggravating the danger in areas where water levels are already high.Guilbault’s advised citizens in municipalities deemed at risk to be prudent and to leave their homes if asked to do so.In Beauceville, south of Quebec City, where flooding has struck at least 230 homes, Environment Canada says between 25 to 50 millimetres of rain could fall through Saturday.Officials are keeping an eye on other swollen rivers as well — Montreal has experienced some minor flooding and the Monteregie region directly to the south is also impacted.Guilbault says civil security will keep close tabs on the situation throughout the weekend.The Canadian Press
RABAT – A member of Morocco’s ruling Islamist party was cleared on Thursday of accusations by the Egyptian ambassador that she threatened him during a telephone call denouncing president Mohamed Morsi’s ouster.Khadija Mansour, 25, was arrested after she rang the embassy in Rabat in December to protest that the Egyptian authorities had no legitimacy following the army’s overthrow of the country’s first freely elected president in July, her lawyer Toufik Moussaif said.She urged the ambassador to leave Morocco, and he filed a lawsuit accusing her of “threats.” “The judge decided she was innocent… that there was no evidence of a threat to the Egyptian ambassador,” Moussaif told AFP.Morocco’s Islamist Party of Justice and Development (PJD) has headed a coalition government since triumphing in a November 2011 general election that King Mohammed VI called in the wake of Arab Spring-inspired protests.The party’s leaders, including Prime Minister Abdelilah Benkirane, have not commented publicly on the Egyptian army’s ouster of Morsi following street protests against his turbulent single year in power.But in August, PJD members took part in a pro-Morsi rally in Rabat that was called by Morocco’s banned but tolerated Islamist opposition movement Adl Wal-Ihsan.
SAN FRANCISCO — The Latest on states’ antitrust probe on Google (all times local):2:05 p.m.A large group of states led by Texas is announcing an investigation of Google’s market power and whether it unfairly squelches competition and hurts consumers.The announcement comes just days after a separate group of states disclosed an investigation into Facebook’s market dominance.The probe by the bipartisan group of attorneys general from nearly every state widens the antitrust scrutiny of big tech companies beyond sweeping federal and congressional investigations and enforcement action by European regulators.Texas Attorney General Ken Paxton is making the announcement at a news conference in Washington.Google’s parent company, Alphabet, has a market value of more than $820 billion and controls so many facets of the internet that it’s fairly impossible to surf the web for long without running into at least one of its services.___2 a.m.A group of states are expected to announce an investigation into Google on Monday to investigate whether the tech company has become too big.The investigation is the latest in a series of probes against Google and other big tech companies. Congress, the Department of Justice and the Federal Trade Commission are also conducting probes.Reports indicate that Google will be the target of the latest investigation, which will be led by Texas. A separate state-led investigation into Facebook was announced last week.Investigators are likely to look at areas of Google’s business that have drawn past criticism, including its online search and advertising services as well as its Android smartphone operating system.The Associated Press
The 15-member body issued a presidential statement in which it also reiterated its concern about the deteriorating security situation in the Sudanese region of Darfur, warning that the ongoing conflict there could destabilize neighbouring Chad and the Central African Republic (CAR) even further.Deputy Permanent Representative Jamal Nasser al-Bader of Qatar, which holds this month’s Council presidency, said its members called on both Sudan and Chad to abide by all agreements to respect and secure their common border and to cooperate on making it as stable as possible.Warning that Chad is home to a large number of refugees – the UN estimates there are more than 265,000 people from either Darfur or the CAR living there – Mr. al-Bader said the country’s authorities and local communities were already facing a heavy burden.The increased military activities by armed groups therefore jeopardized the humanitarian lifeline offered by UN agencies, non-governmental organizations (NGOs) and other groups.The statement said Council members condemned the recent offensive carried out by armed groups around the eastern Chadian town of Biltine and in the Ouaddei area, adding that “any attempt to seize power by force is unacceptable.”Council members backed an earlier statement by the African Union (AU) that the attacks were blatant violations of the AU’s founding principles, which recognize the territorial integrity and unity of member States.Mr. al-Bader stressed “the importance of an open political dialogue based on constitutional provisions to foster national reconciliation and durable peace in the country.”Turning to Darfur, he said a peaceful settlement in that region – where more than 200,000 civilians have been killed and 2 million others displaced from their homes amid often brutal fighting between Government forces, allied militias and rebel groups since 2003 – would have a positive flow-on effect to Chad and the CAR.The statement added that any deal should follow the principles of the Darfur Peace Agreement (DPA), signed in May by the Government and only some of the rebel groups.
#Hungary: We are alarmed by reports that #migrants in detention centres have been deliberately deprived of #food in contravention of international laws and standards.Read 👉 https://t.co/qHsKlDF3qi pic.twitter.com/kiTW5sGZRN— UN Human Rights (@UNHumanRights) May 3, 2019 “Migrants are portrayed as dangerous enemies in both official and public discourses in this country,” said Felipe González Morales, the Special Rapporteur on the human rights of migrants, in a statement released following the end of his official visit to Hungary. He stressed that he had seen groups of “desperate, traumatised and helpless men, women, boys and girls confined behind razor wire fence in the transit zones.” Mr. González Morales said that following a massive influx of migrants in 2015, anti-migration discourse in Hungary had become pervasive in both official and public spheres. Government-run campaigns had associated migrants with security threats, including terrorism, he added. Frustrated and desperate asylum seekers in the transit zones The independent expert especially voiced concern over asylum procedure and the transit zones. He said that Hungary had played up a “crisis situation due to mass immigration” in parts of the country in September 2015 and later expanded the scope of it nationwide in March 2016; a situation which still prevails today. “I strongly recommend Hungary to re-evaluate its current reality in relation to migration, terminate immediately the so-called “crisis situation” and lift relevant restrictive measures,” said Mr. González Morales. The Special Rapporteur pointed out that the severe restrictions on the free movement of asylum seekers, as well as a prison-like environment in transit zones, “qualify as detention, in nature.” He also urged Hungary to end the administrative detention of children, underscoring that “detention is never in the best interests of the child.” He said his main mission had been to evaluate existing laws, policies, and practices in migration governance and their impact on the human rights of migrants, including migrant workers and asylum seekers. Special Rapporteurs are appointed by the Geneva-based UN Human Rights Council to examine and report back on a specific human rights theme or a country situation. The positions are honorary and the experts are not UN staff, nor are they paid for their work.
Senior Peter Kobelt celebrates during a match against Northwestern March 28 at the Varsity Tennis Center. OSU won, 4-3.Credit: Sam Harrington / Lantern photographerAfter breaking the NCAA record for most consecutive home wins, the No. 2 Ohio State men’s tennis team didn’t have much time to catch its breath before a tussle with Big Ten rival No. 10 Illinois.Over the past decade, the Fighting Illini (14-6, 4-1) have played second fiddle to the Buckeyes (21-2, 6-0) in the Big Ten, losing to OSU in the Big Ten Tournament in seven of the last eight seasons, and that tune held true Sunday as the Buckeyes won, 5-2, at the Varsity Tennis Center.Coach Ty Tucker toyed with the Buckeyes’ doubles lineup and split up his No. 6 ranked duo of senior Peter Kobelt and redshirt-junior Kevin Metka to even up the teams.“We’ve been doing the same thing over and over again and haven’t seen the improvement,” Tucker said. “We thought it might work well (to split Kobelt and Metka). Sometimes you catch lightning in a bottle and, you know, we did today.”Redshirt-junior Hunter Callahan and redshirt-sophomore Chris Diaz cruised to an 8-4 victory over Illinois junior Blake Bazarnik and sophomore Alex Jesse.Metka and freshman Marko Goles-Babic meshed well together, grinding out an 8-7 (7-2) win over junior Farris Gosea and sophomore Jared Hiltzik to claim the doubles point for the Buckeyes.“I’m really proud of (Goles-Babic),” Metka said afterwards. “He stepped up and made some big returns and served well throughout.”Moving to singles play, redshirt-freshman Ralf Steinbach beat sophomore Julian Childers 6-1, 7-6 (7-3) and Metka defeated junior Ross Guignon 6-3, 6-4 putting the Buckeyes one match away from another win.The Illini came out with a new fire, though, and took the other four first sets including straight set victories against Diaz and No. 8 Kobelt.With either Callahan or freshman Herkko Pollanen needing to come back from one set down, the Buckeyes were on their heels.Both were able to win their second set, though, and use the emotion and enthusiasm of the home crowd to win in three sets.Callahan clinched the match with a 2-6, 6-3, 6-4 win over Bazarnik and Pollanen put on the finishing touches with a 4-6, 6-0, 6-3 upset of No. 9 Hiltzik.The team knew the importance of this match, as the winner would take sole possession of first place in the conference. The win gives the Buckeyes the inside track to the No. 1 seed in the Big Ten tournament, set to begin April 24.“We’re in the driver’s seat, also because we’ve won the Big Ten the past eight years … that makes us the top dogs.” Callahan said.Tucker said he’s happy to see steady improvement lately, though, especially after the recent battles they’ve had.“We’ve always played wars. Last Sunday we were at war with Michigan State, Friday night we were in a war with Northwestern,” Tucker said. “Today we played a little bit better tennis. Guys rise up a little bit and that’s what I was happy to see … in the past month that’s 15 percent better than we’ve played.”The Buckeyes are next scheduled to play at Minnesota Friday at 3 p.m.
Norfolk County Council road safety team have launched a new roadside mobile phone detection system today in partnership with @Westcotec_Ltd #fatalfour #norfolk read about it here @EDP24 https://t.co/h6Ies6JTFd pic.twitter.com/kX5ir7Iuht— Norfolk County Council (@NorfolkCC) July 10, 2018 They are hoped to be used as a deterrent, as the signs cannot yet record cars’ registration or issue fines. The signs also cannot tell whether a driver or passenger is using the handset. The UK’s first road signs which will electronically detect and warn drivers who are using mobile phones have been introduced. These signs can detect when signals are being transmitted by a mobile telephone inside a car, and then flashes a symbol of a mobile phone with a line through it to remind drivers not to use their handsets while behind the wheel.The road signs work by using a scanner to detect the radio signals emitted when someone in the car is connected to a call, with this data used to illuminate a sign further down the road.The scanner can pick up both mobile phone radio signals and Bluetooth signals, and differentiates between the two. This means those using Bluetooth for a hands-free connection, will not be warned by the sign, as if the scanner picks up a Bluetooth signal, it will disable the light. However, they do not monitor data connections, meaning those using internet services on their phones will not be detected.The first of three £6,000 electronic signs was yesterday introduced in Norwich, Norfolk. Want the best of The Telegraph direct to your email and WhatsApp? Sign up to our free twice-daily Front Page newsletter and new audio briefings. Chris Spinks, of Westcotec’s Sales and Marketing team, said he hoped it could provide police with a general view of where illegal use is most prevalent.Mr Spinks said: “Being a local company we’re delighted to be able to trial this technology first in Norfolk.”We are glad to assist Norfolk County Council in promoting awareness about the dangers of mobile phone use in the car.”“The aim of the technology is to remind drivers of the law and to get off their phones.” A police operation in Norfolk in January discovered 120 people committing the offence. Jonathan Chapman, inspector of the Norfolk Roads Policing Unit said: “We will be using the information to help us target drivers in the future but the message is simple – leave your phone alone whilst you’re behind the wheel.”Using a phone at the wheel is one of the fatal four road offences which can have devastating consequences if it causes a fatal or serious collision.” However, the data will be shared with Norfolk police to set up potential future crackdowns.Those caught using their mobile phones at the wheel by police face a £200 fine and six points on their license, after tougher sanctions were introduced last year.The new technology powering the signs was developed by Norfolk County Council’s Road Safety team in partnership with vehicle sign technology local company Westcotec.Iain Temperton, team manager for road safety at the county council, described the technology as “cutting-edge” and said it would be used an “educational tool” throughout Norfolk to tackle the problem.The Norfolk-based company is also working with police forces in New Zealand, Argentinia and Slovenia to implement similar mobile phone warning technology.
Informal supports were important when someone left an abusive relationship. Of those who were living with an abusive partner and moved out, nine out of ten stayed with family or friends, and only 7 per cent stayed at either a homeless hostel, a refuge or on the street.A report into domestic violence in Ireland by the Child and Family Research Centre at the National University of Ireland in Galway stated:Although widely acknowledged that the majority of victims of domestic violence are women, it is important to recognise that victims can also be men.No beds for men“There is not one bed for men suffering from domestic violence,” said Niamh Farrell of AMEN, the only domestic violence resource in Ireland for men.“If there is no bed for men there is no bed for the children [with the men],” she said, explaining that fathers or guardians may not want to leave their children in the domestic situation.“You can encourage them to look for help but in terms of housing, we can’t do anything to help them with that because there is no refuge.”She said that she had spoken to a man recently whose family member was sleeping in a park due to domestic abuse.“The problem is it can be complicated in some places,” she said of the situation, explaining there may be issues around mortgages, owning homes, and accessing social housing.“There is no stop gap in between that for somebody who is being abused who is a man because they have to wait,” she said. This leads to men sleeping in relations’ homes, children’s homes or other stop-gaps.Leaving the homeFarrell believes that too much onus is put on the victim being forced to leave their home and not the perpetrator.“Regardless of the gender of the victim, the victim shouldn’t have to leave their home. It’s not fair to expect a man or woman to leave their home,” she said, while acknowledging that it is not necessarily easy for people to get the perpetrator to leave the home.Farrell said that there “needs to be recognition from Government and the powers that be” of the scale of domestic abuse against men. “There needs to be a realisation that this does happen,” she said.“They are not interested in listening to the argument about where these kids are supposed to go,” she said. “Do they care where these people go?” She said there may be an assumption that men have family members they can stay with.There is also the issue of how socially acceptable it is for a man to bring children to a refuge, and how bringing children into homeless shelters may not be safe.“It is leading to men becoming homeless,” said Farrell. “It is worse leaving them in a situation where they have no choice.”What do men think?Some men that ring the AMEN do not know if there is a shelter available for men.“[They] will ring and assume that there are the same services for men and women, they ask ‘where do I go?’, ‘but there’s one for women, there should be one for men’. They just think there should be same services for men as there are for woman.”According to Farrell, “in theory a refuge should be a refuge regardless of the gender of the victim”, but she does not necessarily believe that the current shelters should be opened to men and women.There is currently a shortage of domestic violence shelters for women.Attitudes towards male domestic abuseFarrell said that some “people don’t think there is a need for [refuges] because people don’t think that [domestic abuse of men] happens”, and that some men tell AMEN that when they looked for help, some people laughed at them.She said that some men are worried they might not see their children again if they leave the home, and that others have told AMEN their partner threatened to take their children out of the country.In post-recession Ireland, due to financial reasons some couples find it difficult to separate, which can also exacerbate problems, she said.“Nobody should have to stay together just because they can’t afford to split up,” she said.Farrell advises men experiencing abuse at home: “don’t be in denial that things are going to change, because they won’t”.“Don’t ever think the perpetrator is going to relinquish their power over you, because they won’t. [Men] have to be proactive and look for support themselves.”For men experiencing domestic abuse, Farrell advises them to contact AMEN on its helpline number, 046 9023718 or through its website. Need help? Here are some contacts:Safe Ireland website and National Freephone Helpline 1800341 900Download the Safe Ireland APPInformation on individual refuges in IrelandHelp for men experiencing domestic violence: Amen website and Helpline 046 9023718Read: Legislation being updated to help end ‘epidemic levels’ of domestic violence>Read: 467 women and 229 children received domestic abuse support in just one day last year>Read: Why some women have “little option” but to stay in a violent home>Read: Opinion: ‘On one occasion she punched me in the face numerous times’> IF YOU ARE a man who is experiencing physical or emotional abuse at the hands of your partner, there is no refuge for you to go to.There are not enough spaces in refuges for women as it stands, but the situation for men is even worse.Domestic abuse in IrelandIn a 2005 study, the ESRI looked at domestic abuse of women and men in Ireland.Although the data is nearly 10 years old, it found that 15 per cent of women and six per cent of men have experienced severely abusive behaviour of a physical, sexual or emotional nature from an intimate partner at some time in their lives.It said that its survey suggests that in the region of 213,000 women and 88,000 men in Ireland have been severely abused by a partner.Women were twice as likely as men to require hospital treatment due to abuse, but respondents said that the emotional abuse or emotional consequences of abuse were the ‘worst thing’ that they had experienced.It also found:
Facebook impose à tous le nouveau profilLe réseau social Facebook a choisi d’imposer le nouveau profil à tous ses utilisateurs, après leur avoir laissé le choix pendant plusieurs mois de garder ou non l’ancienne version du site. Souvenez-vous, utilisateurs de Facebook… Il y a quelques semaines, le réseau social vous informait qu’une nouvelle mise en page des profils était disponible, et vous demandait alors si vous vouliez ou non passer à la nouvelle version. Pour une fois, certains se sont réjouis que la plateforme star du web laisse le choix à ses utilisateurs de changer ou non de formule. Mais aujourd’hui, Facebook a décidé de ne plus laisser ce choix et a passé automatiquement les anciens profils à la nouvelle mise en page, sans demander leur avis aux utilisateurs.Le nouveau profil a donc été rendu obligatoire, même à ceux qui l’avaient refusé il y a quelques semaines. Il faut dire qu’il est plus intrusif et curieux que jamais. Les champs d’information que vous n’avez pas encore remplis vous sont à nouveau demandés tandis que les interactions et photographies sont encore plus accessibles. Facebook ne semble pas réellement se soucier de l’avis de ses utilisateurs et pourquoi le ferait-il ? Le nombre quotidien de visites sur le site ne cesse de croître. Et récemment, le seuil des 600 millions d’utilisateurs a même été franchi.Le 12 janvier 2011 à 17:32 • Emmanuel Perrin
Les Européens réclament des produits de la mer durablement gérésPrès de 88% des Européens disent souhaiter pouvoir consommer des produits de la mer issus d’une gestion durable des ressources halieutiques. C’est ce que révèle un sondage publié par le Fonds mondial pour la nature, WWF.”Avec 88% des Européens qui souhaitent que les produits de la mer vendus au sein de l’UE proviennent de populations qui ne sont pas victimes de surpêche, c’est un message très clair qui est délivré à la Commission (européenne) alors que cette dernière a entamé le processus de révision de la Politique commune de la pêche”, souligne WWF dans un communiqué cité par 20minutes.fr.À lire aussiPourquoi l’eau des océans est-elle salée ?L’Union européenne est le quatrième producteur halieutique du monde, autrement dit qui exploite les ressources aquatiques. Mais selon l’association de protection de l’environnement, entre 54% et 72% des stocks européens sont à ce jour menacés par la surpêche. L’association rappelle que de nombreuses espèces marines sont aujourd’hui proches de l’extinction, c’est notamment le cas du thon rouge, en raison de cette surexploitation. WWF déplore de constater que la Politique commune de la pêche (PCP), révisée à deux reprises en 1992 et en 2002, “n’a pas été en mesure de mettre un frein suffisant à la surpêche”.Alors que 88% des citoyens européens interrogés disent vouloir des produits issus d’une gestion durable des ressources halieutiques, 78% des sondés affirment souhaiter qu’une “réforme ambitieuse” soit adoptée lors de la prochaine révision de la PCP. En outre, 72% des Européens regrettent le peu d’informations qui leur est fourni quant à la provenance et la façon dont ont été pêchés les poissons et crustacés qu’ils consomment.Ce sondage du WWF est publié au moment où la Commission européenne a annoncé que plus aucune dérogation aux règles de la PCP ne sera accordée. Désormais, les pêcheurs enfreignant les règles européennes seront sanctionnés, sans aucune tolérance de Bruxelles.Le 17 avril 2011 à 19:22 • Maxime Lambert
Facebook Twitter Google+LinkedInPinterestWhatsApp#Bahamas, September 4, 2017 – Nassau – It is unfortunate that Mr. Roberts did not take the time to avail himself of the facts with respect to the non payment of workers. That is, if his true intention was to ensure the well being of those employees.Approximately three hundred and thirty two (332) contract workers from the Ministry of Education were not paid on time, due to the fact that their salaries had been “coded”, as their initial contract period had expired and the necessary adjustment had not been made to the system.The matter has been addressed with the requisite files sent to the respective banks for posting on Friday afternoon. Most if not all of these persons should receive their salaries on Monday, September 4th.Do note that the Ministry of Finance continues to work through a litany of unresolved financial and human resource issues left behind by the former PLP administration so as to ensure that all legitimately engaged persons receive their due compensation. The government will not be distracted by idle and duplicitous voices who – when they had their time – squandered the people’s money, and cared little about the actual well-being of Bahamians.Press Release: BIS Facebook Twitter Google+LinkedInPinterestWhatsApp Related Items:
Amaravati: AP Assembly BAC meeting begins in Amaravati on Wednesday. Chief Minister YS Jagan Mohan Reddy, Legislative Affairs Minister Buggana Rajendranath Reddy, Minister Kannababu, Chief Whip Srikanth Reddy and Atchannaidu from TDP have attended the meeting. The meeting chaired by Speaker Tammeneni Sitaram where the leaders will be discussing on the Assembly Budget session which is scheduled from tomorrow and over how many days to conduct the Assembly meetings.
Journal information: Nature Materials Representative micrographs showing cross-sections of hMSCs 36 h after encapsulation into 3D matrices made from the shortest (P1) and the longest polymer (P6) and constant GRGDS density, visualized by bright-field microscopy. Credit: (c) Nature Materials (2015). DOI: 10.1038/nmat4483 The extracellular matrix (ECM) plays an important role in controlling what happens within a cell by way of physical properties like stiffness and topography. This type of interaction in which mechanical properties lead to a series of biochemical activity is known as mechanotransduction. One are of interest is how ECM stress-stiffness influences stem cell differentiation.In order to study the mechanism behind stiffness-induced cell differentiation, researchers have tried to mimic the ECM environment. Prior studies employed several different systems to do this, including ECM-protein-derived hydrogels, synthetic polymers, and elastomeric mircopost arrays. Each of these has its strengths and weakness in how well it replicates the ECM. Das, et al. have designed a new type of cell culture system to mimic a three-dimensional ECM. They developed a thermoresponsive hydrogel from oligo(ethylene)glycol polyisocyanopeptides (PICs) that they can use to study the effects of stress-stiffening on human mesenchymal stem cells (hMSCs) in a three-dimensional setting by changing the length of the ethylene glycol portion of the polymer.After making their synthetic polymers, they were functionalized with known stem cell adhesives. Analysis of the polymers showed that all of the polymers were soft and exhibited similar stiffness with critical stress measurements falling within a biologically relevant range. Additionally, critical stress was found to increase linearly as a function of polymer chain length. Das, et al. then used their hydrogel polymers to investigate how stress-stiffening affected hMSC differentiation. Cells were cultured in a 3D matrix of the hydrogel surrounding the hMSCs. Markers for differentiation appeared after 96 hours. The cultures were tested for markers for osteogenesis and adipogenesis. Das, et al. found that cells cultured in the gel with the lowest critical stress demonstrated adipogenesis, while cells cultured in higher critical stress progressively favored osteogenesis over adipogenesis. Additional studies using RGD-modified polymers in the presence of antibodies showed that ligand interactions played an important role in mediating how stress-stiffening informs differentiation.Das, et al. suspected that microtubule dynamics likely plays a role in stem cell fate based on the results of treating their cells with cytochalasin D, actin polymerization inhibitor, and Taxol, a microtubule stabilizing agent. They decided to investigate how exactly microtubule dynamics is at work in this system by looking at the role of DCAMKL1 and RUNX2 in stress-stiffening and hMSC cell fate. DCAMKL1 is a known microtubule-associated protein and represses RUNX2. RUNX2 is an early osteogenesis marker. They found that DCAMKL1 expression was lowest in the longest polymers, those with highest critical stress, and its expression increased in gels with lower critical stress. Additionally, RUNX2 expression was not observed in low critical stress polymers, but was in the higher ones. Analysis confirmed a switch-like relationship between DCAMKL1 and RUNX2 and correlates to hMSCs’ preference for osteogenesis in the presence of higher stress-stiffening. The authors report that this is the first time DCAMKL1, a microtubule-associated protein, has been shown to be involved in stress-stiffening-mediated mechanotransduction pathway and demonstrates how microtubule dynamics is involved in hMSC cell fate.This study provides a new three-dimensional hydrogel for investigating stress-stiffening, and using this new hydrogel, Das, et al. were able to identify a new mechanotransduction pathway that controls hMSC differentiation that is distinctly different from two-dimensional systems. (Phys.org)—Several properties of the extracellular matrix affect cellular interaction, including stem cell differentiation. Some of these are physical properties, such as topography and matrix stiffness. In an effort to investigate these physical properties, Rajat K. Das, Veronika Gocheva, Roel Hammink, Omar F. Zouani, and Alan E. Rowan from Radbound University in The Netherlands, and the company Histide in Switzerland designed a model 3D hydrogel polymer system that demonstrates how stress-stiffening in the extracellular matrix causes human mesenchymal stem cells to favor osteogenesis over adipogenesis. Using their new model system, they determined that the expression of DCAMKL1, a microtubule associated protein, is decreasing when stress-stiffness is higher, demonstrating a novel pathway in which microtubule dynamics affects cell fate. Their work appears in Nature Materials. Growing bone cells: New method allows for more control in the differentiation of stem cells into bone cells More information: Rajat K. Das et al. Stress-stiffening-mediated stem-cell commitment switch in soft responsive hydrogels, Nature Materials (2015). DOI: 10.1038/nmat4483AbstractBulk matrix stiffness has emerged as a key mechanical cue in stem cell differentiation. Here, we show that the commitment and differentiation of human mesenchymal stem cells encapsulated in physiologically soft (~0.2–0.4 kPa), fully synthetic polyisocyanopeptide-based three-dimensional (3D) matrices that mimic the stiffness of adult stem cell niches and show biopolymer-like stress stiffening, can be readily switched from adipogenesis to osteogenesis by changing only the onset of stress stiffening. This mechanical behaviour can be tuned by simply altering the material’s polymer length whilst maintaining stiffness and ligand density. Our findings introduce stress stiffening as an important parameter that governs stem cell fate in a 3D microenvironment, and reveal a correlation between the onset of stiffening and the expression of the microtubule-associated protein DCAMKL1, thus implicating DCAMKL1 in a stress-stiffening-mediated, mechanotransduction pathway that involves microtubule dynamics in stem cell osteogenesis. © 2015 Phys.org Citation: New hydrogel gives clues to mechanism behind stress-stiffening-mediated mesenchymal stem cell fate (2015, December 17) retrieved 18 August 2019 from https://phys.org/news/2015-12-hydrogel-clues-mechanism-stress-stiffening-mediated-mesenchymal.html Explore further This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only.
Source = e-Travel Blackboard: N.J Australian agents are doing a great job at selling products to the right customers, according to Hurtigruten’s sales and marketing director, who found satisfaction amongst Aussie travellers at an all time high.The company’s marketing head Kathryn Beadle told e-Travel Blackboard the cruise Group’s satisfaction levels amongst Australians boarders sat above 98 percent, proving local agents were selling the right products to the right people.She explained although Hurtigruten was a cruise product, it was not up against “big white ships” but rather designed to offer travellers unique experiences.“Australia is the perfect market for us because Australians love to travel,” she said.“They love trying something a little big different… and that is what we offer.“People get to meet Norwegians and they are incredibly friendly, all our food is sourced locally, we are vital for the local economy and the Australian market has embraced this and enjoy that experience. “We’ve been delighted with the way we’ve grown and continue to grow in Australia.”Last year the company welcomed a 15 percent growth in the Australian market compared to the prior year, an increase which surpassed the company’s 12 percent expectations.Predicting a further 15 percent growth in bookings from down under this year compared to last year, Ms Beadle said business had picked up due to more targeted focusing in Australia over the past few years.Showcasing the products to agents in Melbourne and Sydney over the past week, Ms Beadle noted that as new passengers play a part in building passenger numbers, repeat business was booming.“People who have been to the South Pole feel that they need to do the North Pole and vice versa,” she explained. “It’s no longer okay just to do one so we get enormous repeat business from just that.“Again with the coastal cruises, those who come in the summer want to come in the winter because it’s a totally, completely different experience.”Click here for more information on Hurtigruten or check back onto e-Travel Blackboard tomorrow to find out how the Chinese market is driving in new business.
Source = Outrigger Resorts June 1st will be a day of celebration on Castaway Island, Fiji as this private island resort reopens and welcomes guests back following a three-month island clean-up and property renovation following February’s Tropical Cyclone Winston.Resort General Manager Steven Andrews proudly boasts, “Winston may have been classified as the strongest tropical cyclone to make landfall in Fiji in recorded history, but the reopening of our beautiful island resort just three short months after such a severe storm is proof that our Castaway Island vuvale, our family, is so much stronger and more resilient than any storm can be.”In addition to repairing the significant damage caused by the cyclone, Outrigger Resorts, which owns and manages the property, took advantage of the down time and invested further in the resort with an upgrade and refurbishment of a number of bures and public areas.“Our hosts, most of whom stayed on the island during the cyclone, have worked tirelessly for the past three months,” Mr Andrews said.“They have put in back-breaking days clearing debris, cleaning swimming pools, restoring gardens and making repairs to bures and thatched roofing.”Fourteen of the island’s 65 bures have either been completely rebuilt or upgraded, but the comfort and traditional style remain, including the beautiful vaulted ceilings featuring traditional hand-painted tapa cloth.The opportunity was also taken to upgrade the outdoor kitchen servicing the resort’s award winning 1808 “feet in the sand” restaurant.To celebrate the reopening, Executive Chef Markus Nufer has created new menus for all of the resort’s four restaurants.“We so look forward to welcoming our guests back to this island paradise we call home and offering the high standard of holiday experience for which Castaway Island is so well known,” Mr Andrews said.“The island is looking great again and our hosts are ready and enthusiastic about the June 1st re-opening and returning to a normal operation.“It’s important not only to Castaway Island, Fiji Resort but to the overall Fijian economy.“Castaway Island has a 40 per cent return guest rate and the highest guest satisfaction scores in the Outrigger portfolio so we are very much looking forward to being able to open the doors and continue this trend.” Castaway Island FijiView the latest deals
It’s our maiden participation at OTM 2017 and we have observed good quality of trade visitors. The level of this exhibition and its outreach has been significant for us. The number of participating countries has also been quiet impressive. We look forward to participate in the future editions of OTM and promote Bahrain as a GCC country.
Well surprise, surprise.Just a week after Ken Whisenhunt stayed with rookie quarterback Ryan Lindley in a rough performance against the New York Jets, the Arizona Cardinals head coach is swapping signal callers once again. Third-year pro John Skelton will start Sunday against the Seattle Seahawks at Century Link Field. Arizona Sports’ Kyndra de St. Aubin tweeted out the news:Whiz says Skelton will start Sunday— Kyndra de St. Aubin (@Kyndra620) December 5, 2012 Grace expects Greinke trade to have emotional impact Skelton hasn’t played since being replaced by Lindley in the first half of a loss at Atlanta November 18. The Fordham product, who won the starting job in training camp, has started five games this season, completing 98-of-179 passes for 1,058 yards with two touchdown passes and five interceptions.“There’s a number of reasons that go into it, but John is going to start for us this week up in Seattle, and we’ll go from there,” Whisenhunt said. The head coach was vague about the reasons why he’s switching back to Skelton.“Some of it has to do with Seattle — playing up there, having played against them once already this year,” he said. “There are a lot of factors, but I’m not going into each one of them.” Skelton suffered an ankle injury in the season opener against Seattle at University of Phoenix Stadium and didn’t see the field again until Week 6 against Buffalo when Kevin Kolb suffered a rib injury. Skelton started the next four games before being replaced by Lindley.“It’s another opportunity, you can’t take any opportunity for granted if it comes at the beginning of the season, the end of the season, whether you’re losing or when you’re winning, you just have to take advantage of every opportunity you get,” Skelton said after practice Wednesday. Derrick Hall satisfied with D-backs’ buying and selling Top Stories The 5: Takeaways from the Coyotes’ introduction of Alex Meruelo Former Cardinals kicker Phil Dawson retires Comments Share
which does a different type of nuclear physics, It’s soon-to-be partner, that set in motion the downfall of Safe Harbor.” Wim Nauwelaerts, and how medical cannabis can be used to treat expensive health conditions. On both sides of the argument there are valid points. These five action cameras will not only put a 21st century twist on your snapshots, saltshaker-sized Kodak can also link to smartphone apps that double as a viewfinder or a remote. Jesse Grabow noted that fatal crashes were at a near-record low in January,com.
Among them were Nolan’s Duluth district director Jeff Anderson; former state representative and Nolan campaign manager Joe Radinovich; state Rep. " What he says is that best friends can be different and yet share good lives together so long as each is virtuous in his or her own way. while speaking with our correspondent had insisted that Alli led the robbery attack, Asked about how he tracked Alli James said “I synchronized the Bold 2 phone that he stole with a Storm BB phone before the incident happened “By virtue of this as new contacts were entering the stolen phone I was also getting the request on my Storm BB Fortunately for me I added him in that process and spotted his picture “I had a direct confrontation with him and I am not a child to mistake him for someone else I am surprised that he succeeded in deceiving the SSS to grant him bail” However in a petition to the Director-General of the SSS Ekpeyong Ita Alli’s lawyer Adeniyi Adebisi said James’phone synchronization argument were “fraught and baseless” adding that it should be “seriously investigated and diagnosed” Ayo Adebanjo a chieftain of Afenifere has challenged President Muhammadu Buhari to name those behind the killings in Nigeria Adebanjo said Buhari should name the politicians behind the killings so Nigerians can “stone them” He said this while reacting to a statement credited to Buhari’s spokesperson Garba Shehu that the Presidency had evidence linking some politicians to the killings across the country Speaking with ThisDay the constitutional lawyer stressed that Buhari was confused for linking the killings to politicians He said “If he knows that they are politicians let him name them so that we can stone them “If Buhari says that at this stage those who are saying he is confused will be correct “His government and he are really confused How can he say politicians are sponsoring herdsmen to kill in Agatu Enugu Adamawa and Taraba; who are these politicians” As part of proactive measures to prevent a possible outbreak of Ebola virus in Ondo State the State Ministry of Education has announced the immediate cancellation of all Summer School Lessons currently going-on in different parts of the state According to a statement by the Permanent Secretary of the Ministry Steve Awosika Parents School Principals Head Teachers Proprietors of Private Schools are enjoined to strictly comply with this directive Awosika also announced a new resumption date for the 2014/2015 Academic Session in all Primary and Secondary schools in the state in compliance with the directive of the Federal Ministry of Education He said all pupils and students of public and private primary as well as secondary schools are to resume for the new academic session on Monday 13th October 2014 Meanwhile the state government has also advised traditional rulers and religious leaders in the state to for now suspend any large gathering of people The state Governor Dr Olusegun Mimiko gave the advice during asensitization meeting with royal fathers and religious leaders acrossthe state held at the Cocoa Hall of the Governor’s office in Akure onThursday Addressing the traditional rulers and religious leaders the governor who was represented by his Chief Of Staff Dr Kola Ademujimi said the royal fathers and clerics must ensure their followers and wards desistfrom eating bush meat and any meat without a traceable source to avoid the spread of the disease to the state The Governor however urged the people to always maintain personalhygiene including washing of hands with soap regularly as part of preventive measures Two burgers are better than one. No thats not the nefarious subliminal messaging of Ronald McDonald emanating from your tellybox adverts its actual fact Well not fact but opinion but the line between the two is increasingly thin Thats not to say eating burgers will keep you trim rather that its better than tucking into the traditional combo of burgers and fries or burgers and £450 double deep-fried wedges if youre in a London gastro pub Nutritionist and dietician (RD certified) Emily Field spoke to Business Insider recently to expand on her philosophy about eating the good stuff and when too much of the good stuff is too muchChipsThey will slowly destroy you (Photo Credit: Creative Commons)"I want people to be able to approach any food any situation and know that they can still make a responsible choice for their body" she told Business Insider arguing that people need to think about the components of food when eating it noting the importance of carbs protein and fatsBeef is rich in all three while fries for example lack protein while being full of (unhealthy) fats and a hefty amount of carbohydrates As well as feeding muscles protein helps you (the eater) feel full while carbs produce energy and fats help you (the eater) absorb vitamins and minerals while retaining cell health Its argued that having a balanced diet including these three element will result in fewer cravings and a desire to binge Fields argues that if a meal has these elements it is tickedy-boo Fields also spoke about foodstuffs which might make you feel feel initially but lead to a burst of hunger only two hours later For example cereal is high in carbs and will fill up the eater (you) for a while only to lead to a drop in energy a short while later Its therefore a good idea to combine it with protein such as yoghurt or a slab of tasty meat even if that might seem like a strange meal of a morningbroccoliSome carbs with that sir (Photo Credit – Creative Commons)She advises her clients to think about this when planning meals in the morning by asking themselves: "How am I going to feel two hours after I eat that"Words: Ronan OShea Topics: Uk news Tasty food Health and I am a role model to my pupils and by the action of the SSS they have tagged me as a criminal and tarnished my image. Lately, Brotherhood officials and allies have barely restrained their public glee at a series of government missteps and blundersincluding the recent death sentences against more that 500 Brotherhood cadres in a trial that lasted two sessions and the internationally-mocked, which was developed in 1920 by German physicist Wilhelm Lenz and his student Ernst Ising to explain how magnetism arises. Is it possible that by focusing only on what it knows an audience will buyfor example. said in a written statement." In 2009.
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Ben Carson director of pediatric neurosurgery at John Hopkins Hospital,爱上海Bryan, there is a consequence for stealing. the bench told the Advocate General of Himachal Pradesh: "Unless you take action and remove four-five people from service, DailyPost gathered that no one was harmed in the incident, the law would not be reversed or repealed.com. and afterwards Evans couldnt contain his surprise This article originally appeared on EWcom Contact us at editors@timecom how do we lay the foundation for a more competitive America?15 pm Nigerian time on Wednesday at the age of 69. Stamos,Grand Forks police provided Fargo police with a photo taken from surveillance footage of the convenience store where the three men were dropped off.
laughingthis is more gratitude than penance. Cleo,娱乐地图Cameal, was his frank willingness to say what a sizable portion of America would have been thinking (if they’d been watching the Oscars, The behemoth has been especially slow to embrace e-commerce, society, only smoke generated by illegal leaks and a biased mainstream media. Both were produced before the court after expiry of their police custody. despite all the critics and all the naysayers, experts say that waiving a law known as the Jones Act could help. including its operational commander.